Iva Tolic-Nørrelykke

نویسنده

  • Iva Tolic-Nørrelykke
چکیده

math. In the final years I applied to a large number of conferences and summer schools. I wanted to learn about different fields of research in biology, and even more than that I enjoyed travelling the world (which was otherwise financially impossible). So I visited Italy, Hungary, Argentina, Israel, USA, Portugal, Denmark, and Australia. At a meeting in Argentina I learned about possibilities to combine biology and math. I decided to do my PhD in biomathematics, still at the University of Zagreb. I joined the theoretical chemistry group of Nenad Trinajstic at the Rudjer Boskovic Institute in Zagreb. While I worked on theoretical chemistry, my PhD advisor encouraged me to find a place where I could do theoretical biology. I read the Journal of Theoretical Biology, mainly in the library while visiting my parents, who lived in Zurich at the time, because this journal was not available at my home institute. Soon I found an intriguing topic: modeling of the cytoskeleton as tensegrity (tensional integrity) structures, similar to the sculptures of Buckminster Fuller and Kenneth Snelson. The mechanical stability of these sculptures relies on compression-resisting struts and tension-resisting ropes. In the cell, microtubules correspond to struts and actin cables to ropes. I wrote an e-mail to Ning Wang at the Harvard School of Public Health in Boston, saying that I would be interested in working with him for a year or two. He replied that I could come over and see whether it would work out. So I went to Boston, started a theoretical work on testing the tensegrity model, and attended a lot of lunch and dinner seminars that provided free pizza, because I had no salary for the first few months. After my PhD, I realized I did not want to do theory alone and decided to go back to experiments. Because of personal reasons, I got in touch with the optical tweezers group of Kirstine Berg-Sorensen and Lene Oddershede at the Niels Bohr Institute in Copenhagen. This was an excellent opportunity to learn how to manipulate the cells and the cytoskeleton with laser tweezers, as well as how to combine the approaches of physics and math to address problems in biology. Iva TolicNørrelykke

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Nuclear and Division-Plane Positioning Revealed by Optical Micromanipulation

The position of the division plane affects cell shape and size, as well as tissue organization. Cells of the fission yeast Schizosaccharomyces pombe have a centrally placed nucleus and divide by fission at the cell center. Microtubules (MTs) are required for the central position of the nucleus. Genetic studies lead to the hypothesis that the position of the nucleus may determine the position of...

متن کامل

Cell Polarity: Which Way to Grow in an Electric Field?

Cell polarity can be influenced by an electric field, but the mechanisms behind this response are poorly understood. A new paper shows that fission yeast cells change their direction of growth in an external electric field and suggests mechanisms based on the cortical pH gradient and on electrophoresis of membrane proteins.

متن کامل

tweezercalib 2.0: Faster version of MatLab package for precise calibration of optical tweezers

Title of program: tweezercalib Catalogue identifier: ADTV_v2_1 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/ADTV_v2_1 Program obtainable from: CPC Program Library, Queen’s University of Belfast, N. Ireland Licensing provisions: no No. of lines in distributed program, including test data, etc.: 134 188 No. of bytes in distributed program, including test data, etc.: 1 050 368 Distributi...

متن کامل

Merotelic kinetochore attachment: causes and effects

Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction mechanisms, merotelically attached kinetochores can persist until anaphase, causing chromatids t...

متن کامل

Anomalous diffusion in living yeast cells.

The viscoelastic properties of the cytoplasm of living yeast cells were investigated by studying the motion of lipid granules naturally occurring in the cytoplasm. A large frequency range of observation was obtained by a combination of video-based and laser-based tracking methods. At time scales from 10(-4) to 10(2) s, the granules typically perform subdiffusive motion with characteristics diff...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Current Biology

دوره 21  شماره 

صفحات  -

تاریخ انتشار 2011